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Table 3 The methylation of the gene promoters in glioma patients and their clinical characteristics

From: MiR-185 Targets the DNA Methyltransferases 1 and Regulates Global DNA Methylation in human glioma

Variable Methylation n (%)  
  ANKDD1A GAD1 HIST1H3E PCDHA8 PCDHA13 PHOX2B SIX3 SST
Sex         
   Male 18 (64.3) 15 (53.6) 25 (89.3) 13 (65.0) 20 (76.9) 19 (67.9) 19 (67.9) 27 (96.4)
   Female 11 (91.7) 9 (75.0) 9 (75.0) 7 (70.0) 9 (75.0) 10 (83.3) 10 (83.3) 11 (91.7)
p- vablue 0.076 0.205 0.246 0.784 0.897 0.315 0.315 0.527
Age         
   < 45 y 18 (90.0) 13 (65.0) 17 (85.0) 12 (60.0) 17 (85.0) 18 (90.0) 14 (70.0) 19 (95.00
   ≥45 y 11 (55.0) 11 (55.0) 17 (85.0) 8 (40.0) 12 (60.0) 11(55.0) 15 (75.0) 19 (95.0)
p- vablue 0.013 * 0.519 1.000 0.121 0.077 0.013 * 0.723 1.000
Differentiation         
   Grade I-II 20 (90.9) 16 (72.7) 19 (86.4) 14 (63.6) 18 (81.8) 19 (86.4) 18 (81.8) 22 (100.0)
   Grade III-IV 9 (50.0) 8 (44.4) 15 (83.3) 6 (54.5) 11 (68.8) 10 (55.6) 11 (68.8) 16 (88.9)
p- vablue 0.004 ** 0.069 0.789 0.425 0.350 0.030 * 0.145 0.109
Tumor type         
   A 22 (73.3) 18 (60.0) 27 (90.0) 15 (68.2) 22 (73.3) 23 (76.7) 20 (66.7) 29 (96.7)
   GBM 3 (50.0) 3 (50.0) 4 (66.7) 2 (50.0) 4 (100.0) 3 (50.0) 5 (83.3) 5 (83.3)
   OA 4 (100.0) 3 (75.0) 3 (75.0) 3 (75.0) 3 (75.0) 3 (75.0) 4 (100.0) 4 (100.0)
p- vablue 0.217 0.732 0.289 0.723 0.498 0.407 0.304 0.349
  1. p-values from Chi-square test, *p-value < 0.05, ** p-value < 0.005.
  2. A, Astrocytoma; GBM, Glioblastoma multiforme; OA, Oligoastrocytoma