Genomic instability influences the transcriptome and proteome in endometrial cancer subtypes

Habermann, Jens K; Bündgen, Nana K; Gemoll, Timo; Hautaniemi, Sampsa; Lundgren, Caroline; Wangsa, Danny; Doering, Jana; Bruch, Hans-Peter; Nordstroem, Britta; Roblick, Uwe J; Jörnvall, Hans; Auer, Gert; Ried, Thomas

doi:10.1186/1476-4598-10-132

Molecular Cancer

Table 3 Clinical data and ploidy assessment

From: Genomic instability influences the transcriptome and proteome in endometrial cancer subtypes

Case	Histo-pathology	Ploidy	SSI	Age	FIGO 1988	FIGO 2010	Grade	Metastasis	CGH	ANCA	ANRA	Observation time	Died at month
D01	endometrioid	diploid	35, 0	83	1c	1b	1	no	3191	0.043	0	74
D02	endometrioid	diploid	31, 7	59	1b	1a	1	no	3192	0.087	0	42	42
D03	endometrioid	diploid	45, 3	60	1c	1b	1	no	3193	0.130	0	94
D04	endometrioid	diploid	16, 1	52	1b	1a	1	no	3194	0	0	92
D05	endometrioid	diploid	6, 8	87	1c	1b	2	no	3195	0.043	0.043	15	15
D06*	endometrioid	diploid	13, 2	67	1b	1a	2	no	3196	0.043	0	109
D07*	endometrioid	diploid	17, 6	78	3a	3a	2	yes	3197	0.174	0	4	4
D08*	endometrioid	diploid	13, 7	78	1b	1a	1	no	3198	0.043	0	104
D09	endometrioid	diploid	17, 3	59	1b	1a	1	no	3193	0	0	94
D10	endometrioid	diploid	12, 4	55	1b	1a	1	no	3200	0	0	94
D11	endometrioid	diploid	14, 5	81	1b	1a	1	no	3201	0	0	86
D12	endometrioid	diploid	46, 5	72	1b	1a	1	no	3202	0	0	75
D13	endometrioid	diploid	35, 6	63	1c	1b	2	no	3203	0	0	26	26
D14	endometrioid	diploid	56, 4	51	1b	1a	1	no	3204	0	0	88
D15	endometrioid	diploid	31, 0	53	1b	1a	2	no	3205	0	0	55
D16	endometrioid	diploid	38, 4	66	1b	1a	3	no	3206	0.087	0	53
Ae1	endometrioid	aneuploid	68, 0	82	1c	1b	1	no	3207	0.043	0	146
Ae2	endometrioid	aneuploid	20, 4	80	1b	1a	1	no	3208	0.304	0	71
Ae3	endometrioid	aneuploid	35, 2	69	1b	1a	1	no	3203	0.043	0	107
Ae4	endometrioid	aneuploid	26, 9	46	1b	1a	2	no	3210	0.565	0.087	81
Ae5	endometrioid	aneuploid	35, 5	55	2a	2	3	yes	3211	0.087	0	73
Ae6	endometrioid	aneuploid	30, 7	66	1b	1a	2	no	3212	0	0	63
Ae7	endometrioid	aneuploid	71, 0	79	1b	1a	2	no	3213	0.130	0.043	55
Ae8	endometrioid	aneuploid	59, 6	60	1b	1a	3	no	3214	0.043	0	51
Ae9	endometrioid	aneuploid	61, 7	72	1c	1b	3	yes	5521	0.087	0	42
Au1	UPSC	aneuploid	70, 9	77	3a	3a	3	yes	3215	0.565	0.174	36	36
Au2	UPSC	aneuploid	42, 0	78	4b	4b	0	yes	3216	0.609	0	51
Au3	UPSC	aneuploid	28, 5	66	1c	1b	3	no	3217	0.652	0.043	19	19
Au4	UPSC	aneuploid	59, 7	80	3a	3a	3	yes	3218	0.565	0	27	27
Au5	UPSC	aneuploid	48, 6	90	3	3a	3	yes	3219	0.130	0	9	9
Au6	UPSC	aneuploid	27, 5	88	3b	3b	0	yes	3220	0.478	0.13	17	17
Au7*	UPSC	aneuploid	59, 2	80	1a	1a	0	no	3359	0.348	0.13	7	7
Au8	UPSC	aneuploid	91, 3	83	3a	3a	0	yes	5522	0.087	0.043	10	10

* Arrays did not pass visual quality criteria and were thus excluded from further analysis.
Staging was assessed according to FIGO Committee on Gynecologic Oncology. Ploidy status was defined by image cytometry according to the Auer classification. Observation time is given in months. For CGH, the case number of the database is given http://www.ncbi.nlm.nih.gov/sky/skyweb.cgi. SSI, Stem line scatter index.

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ISSN: 1476-4598

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