Figure 5From: Targeting metabolism with arsenic trioxide and dichloroacetate in breast cancer cellsInhibition of the ETC by ATO. (A to C) The effects of a series of ETC inhibitor treatments were compared to 5 μM ATO (t = 12 hours): (A) MMP by JC-1 staining; (B) ATP levels; (C) ROS levels. (D) Cytochrome C oxidase activity after treatment (5 min) with DCA (5 mM) and/or ATO (5 μM). ** P ≤ 0.001, *** P ≤ 0.0001, NS - not significant (treated vs untreated).Back to article page