Table 2 Summary of the impact of siRNAs to deplete eight proteins in SW480 and HT29 colorectal cancer cell lines treated with oxaliplatin (compared to EC50 of siRNA against GFP).

FBL

a

CCGGAUGGUCUAGUCUAUGCA

Resistance

Sensitivity

b

CCUCAUUAACUUGGCCAAGAA

No change

Sensitivity

c

UUCAUUUGUCGAGGAAAGGAA

Resistance

Sensitivity

d

CUGCGUAAUGGAGGACACUUU

Resistance

Sensitivity

FLJ20758

a

ACCAUUUAGAUUCAACAUUAA

Resistance

Sensitivity

b

CAGGACAGAGAGAGUAAAUUA

Resistance

Sensitivity

c

AACCAGUUAGCUGCUAUAUAA

Resistance

Sensitivity

d

CCCAGGAAAUAGCCUAUUAAA

No change

No change

HNRPK

a

CAGCAAGUUUAUUAAUCAGAA

Resistance

Sensitivity

b

CUCUAGUGUCUUAUUAGUUAA

No change

Sensitivity

c

AUGGAAGUGACUAAUGCUGAA

Resistance

No change

d

UUCCAUUGUAUGCAAAUUGAA

No change

No change

NONO

a

CCAAGUGGACCGCAACAUCAA

Sensitivity

Sensitivity

b

CUGUGUUUGAUUUGUCUCAUA

No change

Sensitivity

c

AGGCUUGACUAUUGACCUGAA

Sensitivity

Sensitivity

d

AACAAACGUCGCCGAUACUAA

Sensitivity

Sensitivity

PABPC1

a

AAACGUAAUUUGGAUUAUAAA

No change

No change

b

CGGGCUCGGAACACACAUUUA

Resistance

Sensitivity

c

GACAAAUCCAUUGAUAAUAAA

No change

No change

d

CCGCACCGUUCCACAGUAUAA

Resistance

Sensitivity

RALY

a

CUCAGCCAAGAUCAAGUUAAA

Sensitivity

Sensitivity

b

CGGGCAGACCCUGGACAUCAA

No change

Sensitivity

c

AAGCAAUGUAACCAACAAGAA

Sensitivity

Sensitivity

d

CACCAUGUCCUUGAAGCUUCA

No change

Sensitivity

RPS7

a

CCGGCUAGUACGCGAAUUGGA

Resistance

Resistance

b

CACGGGCAAGGAUGUUAAUUU

Resistance

Resistance

c

CAGCCGGCUCAUAAAGGUUCA

Resistance

Resistance

d

UUCGAGCGCCAAGAUCGUGAA

Resistance

Resistance

RPS8

a

UGGCUAUGUGCUAGAGGGCAA

Resistance

Resistance

b

AUCGUGCUCAUCGACAGCACA

Resistance

Resistance

c

CUCAGAGUGUUGUACUCGUAA

Resistance

Resistance

d

AAGAGUUGGAGUUCUAUCUUA

Resistance

No change