Figure 6
From: Efficient Blockade of Akt signaling is a determinant factor to overcome resistance to Matuzumab
Proposed model to explain the mechanism of ineffectiveness of matuzumab in vitro and how to overcome it. (A) Matuzumab was not able to induce EGFR down-regulation, with persistent signaling and cell proliferation of gynecological cancer cells. (B) Combination of matuzumab with chemoradiation or PD98059 did not trigger benefits over single treatment. (C) Targeting PI3K with the specific inhibitor LY294002 overcomes resistance to matuzumab in EGFR positive gynecological cancer cell lines.