Figure 3From: Short-chain fatty acid level and field cancerization show opposing associations with enteroendocrine cell number and neuropilin expression in patients with colorectal adenomaCgA protein expression in human colon epithelial cells. The percentage of CgA positive staining cells was calculated in crypts in the field and mid-sigmoid samples. (A) Graphs showing no relationship between butyrate concentration and CgA expression in the field (contra-lateral) but a moderate, almost significant inverse correlation at the mid-sigmoid (r = -0.370; p = 0.053) (B) Graph showing the data as mean ± SEM when grouped into tertiles according to butyrate concentration. In the contra-lateral samples there were no differences seen, but in the mid-sigmoid a significant difference was seen between the low butyrate and high butyrate groups (p = 0.037). (C) Graph comparing butyrate concentration and the percentage of CgA expression in the contralateral (white bars) and mid-sigmoid (filled bars) samples. No significant differences were seen between the field and mid-sigmoid samples in any groups.Back to article page