Figure 5From: Dual induction of caspase 3- and transglutaminase-dependent apoptosis by acyclic retinoid in hepatocellular carcinoma cellsSchematic diagram showing the molecular mechanism by which ACR causes HCC apoptosis by restorating phospho-inactivated RXRα followed by enhanced TG2-mediated crosslinking/silencing of Sp1, thereby reducing EGFR-medicated EGF signaling.Back to article page