Figure 3

Oncomine Analysis: Disease Summary for BRF2. The Oncomine database was queried for BRF2 expression in the available datasets based on the following: cancer type, cancer versus normal, cancer versus cancer, cancer subtype, cancer versus baseline, pathway and drug and outlier analyses. The 'red cells' represents BRF2 overexpression and the 'blue cells' represent BRF2 underexpression. The levels of expression are based on the gene rank percentile. This disease summary was performed using a criterion of a 2 fold change for BRF2 expression and a p-value of 1E-4. Using these stringent criteria for BRF2 expression analysis, we found that BRF2 is highly overexpressed in the following cancer vs normal datasets: gastric, kidney and melanoma cancers. In the cancer vs cancer, multi-cancer datasets, BRF2 is overexpressed in leukemias and lymphomas. The outlier analysis, which is used to determine significant BRF2 expression in a subset of the patient samples, showed that BRF2 is both over- and under-expressed across the analyzed cancers. (Oncomine database).