Figure 2
From: The structural impact of cancer-associated missense mutations in oncogenes and tumor suppressors
Distribution of functional site mutations. Distribution of mutations affecting functional sites in oncogenes (Onc) and tumor suppressors (Sup) compared to distribution of random mutations. A and B, distribution obtained by random sampling of positions in Onc and Sup, respectively. C, distribution of functional site mutations in Onc. ATP and GTP binding sites in Onc are significantly more often mutated than expected by chance. D, distribution of functional site mutations in Sup. Observed distribution does not differ significantly from expected random distribution.