Lung tumor ALDH+ CSCs present longer telomeres. A: FISH analysis on H460 sorted cells demonstrates that ALDH+ cells possess longer telomeres than the negative counterpart. B: Quantification of telomere length confirms that the ALDH+ CSC population has longer telomeres than the negative population. C and D: Treatment with MST312 (0.5 μM) for 120 h reduces telomerase activity in the whole population (H1299 cells) as show by PCR analysis (C) and ELISA (D). Data and error bars show mean ± SEM; *: p < 0.05; **: p < 0.01; ***: p < 0.001.