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Table 1 Correlation of KLB expression and tumor multiplicity in HCC patients

From: Klotho-beta overexpression as a novel target for suppressing proliferation and fibroblast growth factor receptor-4 signaling in hepatocellular carcinoma

 

Down-regulated KLB expression (× < 0.5-fold)

mRNA change not significant (2.0 > × > 0.5)

Up-regulated KLB expression (× > 2.0)

p-value

 

N = 10 (17.86%)

N = 32 (57.14%)

N = 14 (25%)

 

Tumor multiplicity:

    

Single tumor

8

22

4

0.02

Multiple tumors

2

10

10

 

Median age

53.5

59.5

55.3

0.23

Gender:

    

Female

1

7

3

0.81

Male

9

25

11

 

Etiology

    

HBV

7

23

11

1.00

HCV

0

2

1

 

Alcohol

0

1

0

 

Outcome

    

Alive

3

11

4

0.93

Death

4

10

3

 

Recurrence

1

6

3

 

Mean ALT (U/ml)

47.8

65.3

48.5

0.58

Mean AST (U/ml)

63.8

70.6

67

0.95

Mean AFP (U/ml)

45550

19734

14240

0.43

Tumor histology:

    

Poor

5

9

1

0.72

Well

1

5

0

 

Mean diameter

10.03

8.35

9.32

0.64

Cirrhosis:

    

Positive

7

19

11

0.43

Negative

3

13

3

 

Vascular Invasion:

    

Yes

7

16

7

0.52

No

2

13

4

 
  1. Using the classification in Figure 1 to stratify patients based on KLB expression in HCC tumors relative to their respective normal tissues, Fisher's exact test was performed with respect to clinicopathological features.
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Molecular Cancer

ISSN: 1476-4598