Figure 3

(a) F-actin and rhoA localization: Middle Z planes of LCM images showing transmission images (upper panel) and distribution of F-actin (middle panel) and rhoA (lower panel) in unstimulated normal and CML PMNL and those stimulated with fMLP (0.5 min); U - Uropod, L - Lamellipodia, P - Projection. (b) Proposed model for interactions between GTPases and F-actin: (i) Unstimulated and (ii) fMLP stimulated normal PMNL; (iii) unstimulated and (iv) fMLP stimulated CML PMNL. Bold font indicates crucial regulatory molecules.