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Table 2 SPM risk associated with p27/p21 polymorphisms after index SCCHN

From: Genetic variants of p27 and p21 as predictors for risk of second primary malignancy in patients with index squamous cell carcinoma of head and neck

Genotypes

Total

(No. = 1,292)

SPM-free

(No. = 1,172)

SPM

(No. = 120)

P a

HR (95% CI)b

 

No.

%

No.

%

No.

%

  

P27 T109G

        

   TT (Ref.c)

706

54.6

661

56.4

45

37.5

  

   TG + GG

586

45.4

511

43.6

75

62.5

< 0.001

2.0 (1.5-3.1)

P21 C98A

        

   CC (Ref.c)

1,105

85.5

1012

84.6

93

77.5

  

   CA + AA

187

14.5

160

13.6

27

22.5

0.009

1.7 (1.1-2.6)

P21 C70T

        

   CC (Ref.c)

706

54.6

661

56.4

45

37.5

  

   CT + TT

586

45.4

511

43.6

75

62.5

0.004

1.7 (1.1-2.7)

  1. aχ2 test for differences in the distribution of p21/p27 genotypes between the patients who developed SPM and the patients who did not
  2. bAdjusted for age, sex, ethnicity, tobacco smoking and alcohol drinking in a Cox model
  3. cRef. = reference group
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Molecular Cancer

ISSN: 1476-4598