Antitumor effects of the investigational selective MEK inhibitor TAK733 against cutaneous and uveal melanoma cell lines

von Euw, Erika; Atefi, Mohammad; Attar, Narsis; Chu, Connie; Zachariah, Sybil; Burgess, Barry L; Mok, Stephen; Ng, Charles; Wong, Deborah JL; Chmielowski, Bartosz; Lichter, David I; Koya, Richard C; McCannel, Tara A; Izmailova, Elena; Ribas, Antoni

doi:10.1186/1476-4598-11-22

Molecular Cancer

Table 1 Characterization of oncogenic alterations in melanoma cell lines tested for sensitivity to TAK733

From: Antitumor effects of the investigational selective MEK inhibitor TAK733 against cutaneous and uveal melanoma cell lines

Driver Oncogenic Mutation	Cell Line	Known Oncogenic Alterations
Wild type for BRAF and NRAS	M230	KIT L576P
	M257	CDKN2A R80
	M257	BRAF amplification
	M285	None detected
	M368	None detected
	M375	None detected
NRAS Mutants	M202	NRAS ^Q61L
		EGFR amplification
		CDKN2A homozygous deletion
	M207	NRAS ^Q61L
		MITF amplification
		EGFR L747_P753 > S
		PTEN heterozygous deletion
	M243	NRAS^Q61H homozygous
		PTEN^E156G heterozygous
		CTNNB1_D32Y
	M245	NRAS^Q61K heterozygous
	M245	TP53 ^R273H
	M244	NRAS^Q61K heterozygous
	M296	NRAS^Q61R heterozygous
	M318	NRAS^Q61L heterozygous
	M318	PIK3CA ^C420R
	SBCL2	NRAS^Q61K homozygous
	Wn1366	NRAS^Q61L heterozygous
BRAF mutants	M229	BRAF^V600E homozygous
		BRAF amplification
		MITF amplification
		AKT1 amplification
		PTEN heterozygous deletion
	M233	BRAF^V600E heterozygous
		BRAF amplification
		AKT1 amplification
		CCND1 amplification
		EGFR amplification
		CDKN2A homozygous deletion
		PTEN homozygous deletion
	M238	BRAF^V600E heterozygous¹
		CDKN2A homozygous deletion
		PTEN heterozygous deletion
	M249	BRAF^V600E heterozygous
		BRAF amplification
		MITF amplification
		AKT2 amplification
		PTEN homozygous deletion
	M255	BRAF^V600E heterozygous
		AKT2 amplification
		CCND1 amplification
		EGFR amplification
		CDKN2A homozygous deletion
	M262	BRAF^V600E homozygous
		AKT1 E17K
		AKT1 amplification
		EGFR amplification
		CDKN2A homozygous deletion
	M263	BRAF^V600E heterozygous
	M263	CDKN2A heterozygous deletion
	M275	BRAF^V600E heterozygous
	M297	BRAF^V600E homozygous
	M297	PTEN^G165X homozygous
	M299	BRAF^V600E heterozygous
	M308	BRAF^V600E heterozygous
		BRAF amplification
		MITF amplification
		AKT2 amplification
		EGFR amplification
		CDKN2A heterozygous deletion
	SKmel28	BRAF^V600E homozygous
		EGFR ^P753S
		MITF amplification
		CCND1 amplification
		CDKN2A heterozygous deletion
		PTEN heterozygous deletion
GNAQ or GNA11	Mel20-06-039	GNAQ^Q209L heterozygous
	Mel20-06-045	GNAQ^Q209P heterozygous
	Mel20-07-070	GNA11^Q209L heterozygous
	Mel20-08-128	GNA11^Q209L heterozygous
	Mel20-09-196	GNAQ^Q209P heterozygous

Legend: ¹Tandem mutation where the codon changed from GTG to GAA.

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ISSN: 1476-4598

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