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Figure 2 | Molecular Cancer

Figure 2

From: Temporally distinct roles for tumor suppressor pathways in cell cycle arrest and cellular senescence in Cyclin D1-driven tumor

Figure 2

Cyclin D1-induced cell cycle exit is associated with early p53 activation and a DNA damage response. A) Western blotting for the indicated proteins in Irbp-Cyclin D1 pineal glands at the indicated ages. HA: HA epitope on the Cyclin D1 transgene. B) Representative immunostaining for γH2AX in Irbp-Cyclin D1 (D1) and wild-type (WT) pineal sections at the indicated ages. C) Quantitative analysis of γH2AX -positive pinealocytes in wild-type (WT) and Irbp-Cyclin D1 (D1) pineal sections at the indicated ages. Columns: mean of measurements from three to six separate mice; bars, SD. D) Western blotting for the indicated proteins in wild-type (WT) and Irbp-Cyclin D1 (D1) pineal glands at the indicated ages. HA: HA epitope on the Cyclin D1 transgene. Hsc70 is a loading control.

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Molecular Cancer

ISSN: 1476-4598