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Figure 4 | Molecular Cancer

Figure 4

From: Temporally distinct roles for tumor suppressor pathways in cell cycle arrest and cellular senescence in Cyclin D1-driven tumor

Figure 4

p18Ink4c loss delays Cyclin D1-induced senescence. A) and B) Western blotting for the indicated proteins in wild-type (WT) and Irbp-Cyclin D1 (D1) pineal glands at the indicated ages. Hsc70 is a loading control. C) Quantitative analysis of Ki67-positive pinealocytes in Irbp-Cyclin D1, p53-/- (D1p53n), and Irbp-Cyclin D1, p18Ink4c-/- (D1p18n) mice of the indicated ages, compared to p53-/- and p18Ink4c-/- controls, respectively. Columns: mean of measurements from three to six separate mice; bars, SD. D) Western blotting for the indicated proteins in Irbp-Cyclin D1 (D1) and Irbp-Cyclin D1, p18Ink4c-/- (D1p18n) pineal glands at the indicated ages. HA: epitope on the Cyclin D1 transgene.

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Molecular Cancer

ISSN: 1476-4598