Figure 1
From: Increased tumorigenesis associated with loss of the tumor suppressor gene Cadm1
Cadm1 null mice succumb to tumor formation faster than their wildtype littermates. a. Cadm1 null mice (Cadm1−/−) and their wildtype littermates (Cadm1+/+) were put on tumor watch from birth, and monitored for the development of spontaneous tumor development. b. Cadm1−/− and Cadm1+/+ mice were whole body irradiated (3.5 Gy) at 6–8 weeks of age then placed on tumor watch, and monitored for the development of spontaneous tumor development. c. The decreased survival of Cadm1 null mice was due to tumor formation, of a variety of types. d. Representative histological images of hematoxylin-eosin stained tumors from Cadm1 null mice in the irradiated cohort, including (i) a splenic lymphoma, (ii) an angiosarcoma in the leg, (iii) a lung adenocarcinoma, and (iv) a hepatocellular carcinoma. All magnifications are x400.