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Table 1 Inflammatory mediators detected in BALF collected the day after the last treatment

From: Enhancement of lung tumorigenesis in a Gprc5a Knockout mouse by chronic extrinsic airway inflammation

Challenge

PBS

NNK

NNK:PBS

NTHi

NTHi:PBS

NNK+NTHi

NNK+NTHi:PBS

Cytokines

   TNF-α

13.4 ± 1.5

67.9 ± 9.5

5.1 *

59.4 ± 2.5

4.4 *

48.5 ± 5.2

3.6 *

   IL-1β

4.1 ± 0.6

18.5 ± 1.2

4.5 *

21.2 ± 2.4

5.2 *

52.5 ± 4.9

12.8 *

   IL-6

1.7 ± 0.4

4.1 ± 0.3

2.4 *

60.8 ± 17.5

35.7 *

128.3 ± 20.5

75.4 *

   IFN-γ

8.8 ± 1.4

95.2 ± 11.7

10.8 *

59.1 ± 5.4

6.7 *

36.1 ± 3.2

4.1 *

   IL-17

0.4 ± 0.1

1.1 ± 0.1

2.7 *

46.9 ± 1.9

117.2 *

19.9 ± 0.3

49.7 *

Chemokines

   KC

4.7 ± 1.3

8.8 ± 1.8

1.9

9.7 ± 0.4

2.1

70.9 ± 10.6

15.1 *

   MIP-1α

1.3 ± 0.3

2.7 ± 1.1

2.1

7.6 ± 0.7

5.8 *

13.8 ± 2.6

10.6 *

   MIP-2

12.9 ± 0.3

22.8 ± 6.8

1.7

19.3 ± 1.1

1.5 *

44.3 ± 1.7

3.4 *

  1. Data are expressed in pg/ml and presented as the mean ± SEM (n = 3), and *= P < 0.05
  2. BALF, bronchoalveolar lavage fluid; NNK, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone; NTHi, non-typeable Haemophilus influenzae; TNF-α, tumor necrosis factor alpha; IL-1β, interleukin 1 beta; IL-6, interleukin 6; IFN-γ, interferon gamma; IL-17, interleukin 17; KC, keratinocyte-derived chemokine; MIP-1α, macrophage inflammatory protein 1 alpha; MIP-2, macrophage inflammatory protein 2.