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Table 1 Inflammatory mediators detected in BALF collected the day after the last treatment

From: Enhancement of lung tumorigenesis in a Gprc5a Knockout mouse by chronic extrinsic airway inflammation

Challenge PBS NNK NNK:PBS NTHi NTHi:PBS NNK+NTHi NNK+NTHi:PBS
Cytokines
   TNF-α 13.4 ± 1.5 67.9 ± 9.5 5.1 * 59.4 ± 2.5 4.4 * 48.5 ± 5.2 3.6 *
   IL-1β 4.1 ± 0.6 18.5 ± 1.2 4.5 * 21.2 ± 2.4 5.2 * 52.5 ± 4.9 12.8 *
   IL-6 1.7 ± 0.4 4.1 ± 0.3 2.4 * 60.8 ± 17.5 35.7 * 128.3 ± 20.5 75.4 *
   IFN-γ 8.8 ± 1.4 95.2 ± 11.7 10.8 * 59.1 ± 5.4 6.7 * 36.1 ± 3.2 4.1 *
   IL-17 0.4 ± 0.1 1.1 ± 0.1 2.7 * 46.9 ± 1.9 117.2 * 19.9 ± 0.3 49.7 *
Chemokines
   KC 4.7 ± 1.3 8.8 ± 1.8 1.9 9.7 ± 0.4 2.1 70.9 ± 10.6 15.1 *
   MIP-1α 1.3 ± 0.3 2.7 ± 1.1 2.1 7.6 ± 0.7 5.8 * 13.8 ± 2.6 10.6 *
   MIP-2 12.9 ± 0.3 22.8 ± 6.8 1.7 19.3 ± 1.1 1.5 * 44.3 ± 1.7 3.4 *
  1. Data are expressed in pg/ml and presented as the mean ± SEM (n = 3), and *= P < 0.05
  2. BALF, bronchoalveolar lavage fluid; NNK, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone; NTHi, non-typeable Haemophilus influenzae; TNF-α, tumor necrosis factor alpha; IL-1β, interleukin 1 beta; IL-6, interleukin 6; IFN-γ, interferon gamma; IL-17, interleukin 17; KC, keratinocyte-derived chemokine; MIP-1α, macrophage inflammatory protein 1 alpha; MIP-2, macrophage inflammatory protein 2.