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Figure 2 | Molecular Cancer

Figure 2

From: The RASSF gene family members RASSF5, RASSF6 and RASSF7 show frequent DNA methylation in neuroblastoma

Figure 2

RASSF6 methylation and correlation to outcome, 1p deletion and MYCN amplification. (A) Combined bisulfite restriction analysis of RASSF6 .PCR products are cleaved with TaqI. Samples from left to right: Kelly, NB69, SK-N-SH, SH-SY-5Y, SK-N-AS, SK-N-BE(2), SK-N-DZ, SK-N-FI, IMR-32, methylated control (MQ), unmethylated control (UQ) and a 50% mixture of methylated and unmethylated control (MQ/UQ). (B) High methylation of RASSF6 is correlated to an unfavorable outcome. (C) High methylation of RASSF6 is highly correlated to 1p deletion and MYCN amplification.

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Molecular Cancer

ISSN: 1476-4598