Genotyped MACC1 SNPs rs4721888, rs975263, rs3735615 and Met variants rs45607832 and rs56391007 in primary colorectal tumors. A) The chromatograms show the wild-type and the MACC1 sequences with the variants. Sites of nucleotide exchanges are indicated by arrow. Location of SNPs in the MACC1 protein structure is marked. Cla: clathrin box, PxxP: proline-rich domain, DD: death domain. B) The sequencing chromatograms of two sequences with Met variants R988C and T1010I are shown. Both variants are in the juxtamembrane domain of the Met receptor. Cys: cysteine-rich domain, Ig: immunoglobuline domain, TM: transmembrane domain, TK: tyrosine kinase domain.