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Figure 6 | Molecular Cancer

Figure 6

From: MicroRNA-98 and microRNA-214 post-transcriptionally regulate enhancer of zeste homolog 2 and inhibit migration and invasion in human esophageal squamous cell carcinoma

Figure 6

Re-expressing EZH2 significantly attenuates the effect of miR-98 and miR-214 on the inhibition of ESCC cell migration and invasion. Eca109 cells were co-transfected with 50 pmol of miRNAs and 1 μg of pcDNA-EZH2 (or empty pcDNA3.1) plasmid. Migration and invasion of cells were analyzed at 72 hr post-transfection. (A) Transwell assay. Photographs represented the cells travelled through the micropore membrane and histogram showed the percentage of migrant cells. (B) Matrigel-coated transwell assay. Photographs represented the cells invaded through the matrigel and histogram showed the percentage of invasive cells. Bars = 100 μm. Data represent mean ± SEM from 4 independent experiments; *, P < 0.05; **, P < 0.01 by t test.

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Molecular Cancer

ISSN: 1476-4598