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Figure 5 | Molecular Cancer

Figure 5

From: Interferon regulatory factor 4 binding protein is a novel p53 target gene and suppresses cisplatin-induced apoptosis of breast cancer cells

Figure 5

IBP regulates sensitivity to cisplatin in MCF-7 cells. (A) IBP expression was analyzed by Western blot in stable IBP-over-expressing MCF-7 cells and IBP-knockdown MCF-7 cells. C1/MCF-7 and MCF-7/RNAi-cont. cells were respective control cells. (B) Cells were treated with increasing cisplatin concentrations, and their proliferation rates were measured with a CCK-8 assay. (C) Cisplatin IC50 values were determined by CCK cell survival assays. In the columns, the mean was derived from at least three independent experiments. A statistical analysis was performed using Student’s t test. *, p < 0.05, significant

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Molecular Cancer

ISSN: 1476-4598