Figure 7
Activated Akt signaling conveys resistance to chemotherapeutic drugs in an isoform redundant manner. MCF10A cells were infected with retroviruses to respectively express empty vector (Babe), Akt1, Akt2 or Akt3 and then treated with various dosages of paclitaxel (A) and doxorubicin (B) for 2 and 5 days. % of viable cells was calculated by setting untreated groups as 100% to which the drug treated cells were compared. Akt-overexpression significantly sustained cell viability in response to treatments by cytotoxic agents (p < 0.05).