LDHA and HIF-1α expression in nevi and melanomas. Boxplots (median with the 25th and 75th percentiles) of LDHA (panel A) and, likewise, HIF-1α (panel B) H-scores of the TMA cores representing nevi, thin primary melanoma, primary thick melanoma, metastatic melanoma (visceral and lymph node metastases). Depicted in each case is the mean of the average of replicate spots with the same histologic diagnosis. Solid bracket lines depict significant (KW test p≤0.05), and the dashed bracket line (panel A) indicates trend for significant (KW test 0.05<p<0.1) pairwise comparisons corrected for multiple comparison testing. Outliers in the analysis are indicated by open circles.