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Figure 3 | Molecular Cancer

Figure 3

From: P276-00, a cyclin-dependent kinase inhibitor, modulates cell cycle and induces apoptosis in vitro and in vivo in mantle cell lymphoma cell lines

Figure 3

Effect of P276-00 treatment induces apoptosis in MCL cell lines : Cell-cycle analysis by PI staining was performed on (A) Jeko-1, (B) Mino and (C) Rec-1, cultured with media alone or IC 50 and 3X IC 50 of P276-00 for the 24, 48, and 96 h time point. Cells were processed and analyzed by flow cytometry as described in Materials and Methods. Histogram shows shift of cells from G1 phase (M1) to apoptotic phase (M4). Results shown are representative of three independent experiments. Percent change in G1 or S-phase cells was normalized to DMSO vehicle control (D) Compiled data shows dose and time dependant increase in apoptotic cells in all three MCL cells (*** p < 0.0001)

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