miR-10a is aberrantly overexpressed in Nucleophosmin1 mutated acute myeloid leukaemia and its suppression induces cell death

Table 2 miR-10a targets in pathways of potential relevance to AML.

Cancer Census Genes		KEGG AML	KEGG apoptosis	KEGG cell cycle	G.O.C. -myeloid related	*NPM1*^mu^t-AML gene array
*n = 366*		*n = 57*	*n = 62*	*n = 124*	*n = 80*	*n = 53*
ARNT	MLLT6	PIK3CA	BAX	CCNB3	KLF4	CENTD1
BCL6	NF2	RARA	BCL2L11	CDK4	NCOA6	ITM2A
CDK4	NONO		CASP9	CDKN2A	PURB	RARA
CREBBP	NR4A3		FOXO3	CREBBP	RASGRP4	SPARC
ERBB2	PDE4DIP		IRAK4	ORC1L
ERCC3	PIK3CA			ORC2L
FANCD2	PTEN			ORDC5L
FOXO3	RARA
FUS	RECQL4
HMGA2	SSX2
MLLT10	WRN

The genes listed in this table are those in each pathway that are also one of the 1071 permissively identified miR-10a targets. n refers to the number of genes in each pathway interrogated for miR-10a targets. The genes linked to each of the heading in this table are listed in supplemental section. The final column refers to genes that were down regulated in three mRNA gene expression profiling studies of NPM1^mut-AML [15–17]. The genes denoted in bold are those that were also stringently identified by all 3 prediction programs. KEGG- Kyoto Encyclopaedia of Genes and Genomes. GOC.- Gene Ontology Consortium

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