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Table 2 miR-10a targets in pathways of potential relevance to AML.

From: miR-10a is aberrantly overexpressed in Nucleophosmin1 mutated acute myeloid leukaemia and its suppression induces cell death

Cancer Census Genes KEGG AML KEGG apoptosis KEGG cell cycle G.O.C. -myeloid related NPM1mut-AML gene array
n = 366 n = 57 n = 62 n = 124 n = 80 n = 53
ARNT MLLT6 PIK3CA BAX CCNB3 KLF4 CENTD1
BCL6 NF2 RARA BCL2L11 CDK4 NCOA6 ITM2A
CDK4 NONO   CASP9 CDKN2A PURB RARA
CREBBP NR4A3   FOXO3 CREBBP RASGRP4 SPARC
ERBB2 PDE4DIP   IRAK4 ORC1L   
ERCC3 PIK3CA    ORC2L   
FANCD2 PTEN    ORDC5L   
FOXO3 RARA      
FUS RECQL4      
HMGA2 SSX2      
MLLT10 WRN      
  1. The genes listed in this table are those in each pathway that are also one of the 1071 permissively identified miR-10a targets. n refers to the number of genes in each pathway interrogated for miR-10a targets. The genes linked to each of the heading in this table are listed in supplemental section. The final column refers to genes that were down regulated in three mRNA gene expression profiling studies of NPM1mut-AML [1517]. The genes denoted in bold are those that were also stringently identified by all 3 prediction programs. KEGG- Kyoto Encyclopaedia of Genes and Genomes. GOC.- Gene Ontology Consortium