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Figure 4 | Molecular Cancer

Figure 4

From: Targeting of MAPK-associated molecules identifies SON as a prime target to attenuate the proliferation and tumorigenicity of pancreatic cancer cells

Figure 4

A. Left panel: Expression of SON in cloned cells (MIA PaCa-2) stably transfected with shSON or shNons. Middle panel: An example image of a nude mouse with a xenograft of MIA PaCa-2 clones stably transfected with shSON or shNons at 4 weeks after inoculation in the subcutis. Right panel: Average growth of tumors from xenografts of MIA PaCa-2 cells stably transfected with shSON or shNons in the subcutis of 4 nude mice. One (*) and 2 (**) asterisks indicate p < 0.05 and p < 0.01, respectively. Error bars denote 1 value of standard error. B. Cell cycle fractions of pancreatic cancer MIA PaCa-2 and PCI-35 cells transfected with short interfering RNA (siRNA) against SON (siSON) or a nonspecific sequence (siNons) as determined by flow cytometry.

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Molecular Cancer

ISSN: 1476-4598