Figure 6From: Molecular mechanism of the camptothecin resistance of Glu710Gly topoisomerase IB mutant analyzed in vitro and in silicoProtein structure and representative interactions that change during the simulations. (A) View of the protein depicted as a gray tube, DNA strand in green and helices of interest are depicted as ribbons: helices 18 and 19 (linker domain) in orange, helix 16 in blue, helix 17 in red, helix 21 in yellow. (B) A closeup of the representative snapshots of the simulations depicting the interactions between helix 16 and helix 21. (C) Same as B but closeup on the interactions between helix 17 and helix 19.Back to article page