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Figure 6 | Molecular Cancer

Figure 6

From: Molecular mechanism of the camptothecin resistance of Glu710Gly topoisomerase IB mutant analyzed in vitro and in silico

Figure 6

Protein structure and representative interactions that change during the simulations. (A) View of the protein depicted as a gray tube, DNA strand in green and helices of interest are depicted as ribbons: helices 18 and 19 (linker domain) in orange, helix 16 in blue, helix 17 in red, helix 21 in yellow. (B) A closeup of the representative snapshots of the simulations depicting the interactions between helix 16 and helix 21. (C) Same as B but closeup on the interactions between helix 17 and helix 19.

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