Triptolide increases miR-204 and decreases Mcl-1 expression resulting in pancreatic cancer cell death. A. Triptolide treatment of MIA PaCa-2 or S2-VP10 cells results in a time and dose dependent decrease of Mcl-1. β-Actin is used as a loading control. B. Treatment of both MIA PaCA-2 and S2-VP10 cells with triptolide significantly increases levels of miR-204 as assessed using real time PCR.