Kaplan-Meier curves for the patients from eight independent breast cancer cohorts. Panels from A to H denote the SIN, FRA, GER, NED, SWE, TWN, USA1, and USA2 cohorts, respectively. The expression of IC30 gene signature predicts poor survival in breast cancer. Red curves are for the IC30 positive patients while blue curves are for the IC30 negative patients. IC30 positive patients were defined as those having a IC30 risk score greater than the group median score. P-values were calculated by log-rank tests for the differences in survival between the IC30 positive and negative groups.