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Table 3 Comparison in gene expression level between ER positive and negative tumors

From: Expression profiling of ion channel genes predicts clinical outcome in breast cancer

Gene symbol

Gene title

Fold changea

Adjusted

P-valueb

ANO1

anoctamin 1, calcium activated chloride channel

2.09

< 0.001

CACNA1A

calcium channel, voltage-dependent, P/Q type, alpha 1A subunit

0.65

0.043

CACNA1D

calcium channel, voltage-dependent, L type, alpha 1D subunit

5.59

< 0.001

CACNA2D1

calcium channel, voltage-dependent, alpha 2/delta subunit 1

1.30

0.033

CACNA2D2

calcium channel, voltage-dependent, alpha 2/delta subunit 2

2.61

< 0.001

CLCA2

chloride channel accessory 2

0.46

0.017

CLIC4

chloride intracellular channel 4

0.75

0.008

CLIC6

chloride intracellular channel 6

5.86

< 0.001

GABRP

gamma-aminobutyric acid (GABA) A receptor, pi

0.20

0.020

GLRB

glycine receptor, beta

3.42

< 0.001

KCNAB2

potassium voltage-gated channel, shaker-related subfamily, beta member 2

0.72

0.013

KCND3

potassium voltage-gated channel, Shal-related subfamily, member 3

2.36

< 0.001

KCNE3

potassium voltage-gated channel, Isk-related family, member 3

0.75

0.003

KCNE4

potassium voltage-gated channel, Isk-related family, member 4

12.64

< 0.001

KCNJ3

potassium inwardly-rectifying channel, subfamily J, member 3

6.22

< 0.001

KCNK6

potassium channel, subfamily K, member 6

1.82

< 0.001

KCNMA1

potassium large conductance calcium-activated channel, subfamily M, alpha member 1

1.45

0.035

KCNN4

potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4

0.42

< 0.001

KCNS3

potassium voltage-gated channel, delayed-rectifier, subfamily S, member 3

1.58

0.028

MCOLN2

mucolipin 2

0.46

0.002

P2RX4

purinergic receptor P2X, ligand-gated ion channel, 4

1.82

< 0.001

SCN7A

sodium channel, voltage-gated, type VII, alpha subunit

1.71

0.009

SCNN1A

sodium channel, non-voltage-gated 1 alpha subunit

2.00

< 0.001

TPCN1

two pore segment channel 1

1.38

< 0.001

  1. aFold change is calculated by dividing the mean expression of ER positive tumor by the mean expression of ER negative tumor.
  2. bP-value is calculated by two-tailed t-test and adjusted by Benjamini & Hochberg correction.
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Molecular Cancer

ISSN: 1476-4598