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Figure 2 | Molecular Cancer

Figure 2

From: Targeted therapy against EGFR and VEGFR using ZD6474 enhances the therapeutic potential of UV-B phototherapy in breast cancer cells

Figure 2

ZD6474 enhances antiproliferative and apoptotic effects of UV-B radiation. (A) The combinatorial effect of ZD6474 (ZD) and UV-B radiation in decreasing cell viability is attributed to both enhanced antiproliferative and apoptotic effects as shown by decreased cell counts by Trypan blue dye exclusion tests. (B) MCF-7 and (C) MDA-MB-468 cells were treated with ZD6474 (ZD) and/or UV-B radiation, and stained with PI for apoptosis measurements using flow-cytometry. The percentage of apoptotic cells is obtained by gating hypodiploid cells. (D) MDA-MB-468 cells were treated ZD and/or UV-B radiation and stained with DAPI, and observed under CLSM in confocal fluorescence (CF) mode and DIC mode and the merged (CF + DIC) image. Red arrows; apoptotic nuclei, green dashed arrows; membrane blebbing, Arrow heads; intact nuclei. Bars; 10 μM. Representative figures of three independent experiments.

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Molecular Cancer

ISSN: 1476-4598