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Table 2 Identified proteins by MS/MS analysis

From: Cathepsin B as a potential prognostic and therapeutic marker for human lung squamous cell carcinoma

Spot No. Protein description Gene name Function Accession no. Theoretical Mr/pI Score No. of pep Fold change
1 Annexin A2 ANXA2 Calcium ion binding P07355 38472/7.56 518 19 ↑5.71 ± 1.9
2 Cofilin-1 CFL1 Rho protein signal transduction P23528 18371/8.26 563 32 ↑3.3 ± 0.9
3 Apolipoprotein A-I APOA1 Metabolism P02647 28078/5.27 632 28 ↓2.3 ± 0.9
4 Peptidyl-prolyl cis-trans isomerase A PPIA Metabolism P62937 17881/7.82 335 19 ↑3.5 ± 1.1
5 Stathmin STMN1 Signal transduction P16949 17171/5.77 84 4 ↑4.9 ± 1.3
6 Calcium binding protein P22 CHP Calcium ion binding Q99653 22442/4.98 37 2 ↑2.1 ± 0.2
7 Myosin regulatory light chain 12A MYL12A Calcium ion binding P19105 19662/4.67 147 9 ↑2.4 ± 0.6
8 Annexin A4 ANXA4 Calcium ion binding P09525 35751/5.85 1024 39 ↓2.2 ± 0.5
9 Heat shock protein beta-1 HSPB1 Molecular chaperone P04792 22782/5.98 168 10 ↑2.3 ± 0.8
10 Glutathione S-transferase P GSTP1 Apoptosis regulation P09211 23224/5.44 342 22 ↑2.1 ± 0.4
11 Glyceraldehyde-3-phosphate dehydrogenase GAPDH Metabolism P04406 35922/8.58 952 36 ↑2.1 ± 0.7
12 Beta-enolase ENO3 Cell proliferation/differentiation P13929 46800/7.73 267 10 ↑2.5 ± 1.2
13 Fructose-bisphosphate aldolase A ALDOA Metabolism P04075 39288/8.39 406 25 ↓3.9 ± 1.4
14 Elongation factor Tu, mitochondrial TUFM Metabolism P49411 49858/7.26 662 33 ↑5.5 ± 2.1
15 Cathepsin B CTSB Migration and invasive P07858 27814/5.23 144 11 ↑5.0 ± 1.1
16 RACK1 GNB2L1 Metabolism P63244 35055/7.60 205 5 ↑4.7 ± 1.6
17 PDZ and LIM domain protein 1 PDLIM1 Structrual component O00151 36513/6.56 131 14 ↑2.1 ± 0.3
18 Acyl-CoA-binding protein DBI Metabolism P07108 10038/6.12 220 5 ↑2.3 ± 0.4
19 Complement factor H-related protein 2 CFHR2 Metabolism P36980 27896/6.52 61 10 ↓4.3 ± 1.2
20 Apoptosis regulator BAX BAX Apoptosis regulation Q07812 21184/5.08 91 9 ↑2.4 ± 0.8
21 HLA class I histocompatibility antigen, A-25 alpha chain HLA-A immune response P18462 38707/5.97 24 5 ↑2.2 ± 0.5
22 BMP and activin membrane-bound inhibitor homolog BAMBI Signal transduction Q13145 25956/8.21 255 12 ↑3.4 ± 0.9
23 mRNA-capping enzyme RNGTT mRNA splicing O60942 52533/8.3 44 9 ↓3.1 ± 0.7
24 Pyruvate kinase isozymes M1/M2 PKM2 Metabolism P14618 57805/7.95 120 14 ↑3.2 ± 1.2
25 Proteasome activator complex subunit 2 PSME2 Proteolysis Q06323 27515/5.44 327 17 ↑4.9 ± 1.5
26 Protein DJ-1 PARK7 Signal transduction Q99497 20050/6.33 566 16 ↑3.2 ± 1.3
27 Transgelin TAGLN Metabolism Q01995 22653/8.87 369 4 ↑2.8 ± 0.6
28 Glyceraldehyde-3-phosphate dehydrogenase GAPDH Metabolism P04406 35922/8.58 345 10 ↑2.3 ± 0.5
29 Voltage-dependent anion-selective channel protein 2 VDAC2 Ion channel P45880 38068/6.33 47 3 ↑3.4 ± 1.0
30 Fibrinogen beta chain precursor FGB Metabolism P02675 55928/7.95 55 14 ↑3.5 ± 0.7
31 Creatine kinase B-type CKB Metabolism P12277 42644/5.35 155 9 ↓2.4 ± 0.8
  1. Upward arrows: Up-regulated.
  2. Downward arrows: Down-regulated.