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Table 3 Detergent resistant membrane (DRM) fatty acids composition of HT29 cells

From: Omega 3 fatty acids chemosensitize multidrug resistant colon cancer cells by down-regulating cholesterol synthesis and altering detergent resistant membranes composition

 

CTRL

AA

DHA

EPA

C16:0

35.973 ± 2.332

31.712 ± 1.344

31.684 ± 1.527

31.238 ± 2.09

C16:1

6.470 ± 1.522

8.098 ± 0.457

6.761 ± 1.409

9.479 ± 0.789

C18:0

14.923 ± 0.789

15.291 ± 0.352

16.787 ± 1.179

14.685 ± 0.971

C18:1

32.203 ± 1.068

30.241 ± 2.900

32.918 ± 2.472

30.065 ± 2.061

C18:2

3.184 ± 0.283

3.252 ± 0.895

2.871 ± 0.281

4.048 ± 1.115

C18:3 ω -3

0.352 ± 0.035

0.610 ± 0.150

0.389 ± 0.015

0.322 ± 0.084

C18:3 ω -6

0.521 ± 0.154

0.326 ± 0.059

0.389 ± 0.138

2.567 ± 1.893

C20:3

0.835 ± 0.160

0.308 ± 0.018

0.690 ± 0.022

0.581 ± 0.085

C20:4 (AA)

3.183 ± 0.477

8.455 ± 1.782**

3.303 ± 0.159

3.466 ± 0.428

C20:5 (EPA)

0.888 ± 0.178

0.589 ± 0.036

1.260 ± 0.353

1.827 ± 0.304*

C22:5

0.394 ± 0.066

0.590 ± 0.133

0.388 ± 0.101

0.565 ± 0.117

C22:6 (DHA)

1.077 ± 0.157

1.069 ± 0.082

2.553 ± 0.494**

1.158 ± 0.178

SFA a

50.895 ± 2.810

47.003 ± 1.387

48.471 ± 1.743

45.923 ± 2.935

MUFA b

38.673 ± 2.231

38.339 ± 3.201

39.679 ± 2.388

39.544 ± 2.518

ω -6

7.202 ± 0.862

12.650 ± 2.766*

6.863 ± 0.338

8.095 ± 1.397

ω -3

2.708 ± 0.311

2.711 ± 0.193

4.591 ± 0.732*

3.872 ± 0.358*

ω -6/ ω -3

2.735 ± 0.234

4.576 ± 0.579**

1.577 ± 0.183**

2.122 ± 0.374

Fold increase c

 

2.403

2.116

2.199

  1. HT29 cells were left untreated (CTRL) or treated with AA, DHA, EPA (50 μM for 48 h).
  2. aSFA: saturated fatty acids; bMUFA: mono-unsaturated fatty acids.
  3. cFold increase: AA, DHA or EPA in treated cells versus AA, DHA or EPA in untreated cells, respectively.
  4. Data are presented as percentage of total fatty acids, mean ± SE (n = 4). Significance versus CTRL: *p < 0.05; **p < 0.01.