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Table 4 Detergent resistant membrane (DRM) fatty acids composition of HT29-dx cells

From: Omega 3 fatty acids chemosensitize multidrug resistant colon cancer cells by down-regulating cholesterol synthesis and altering detergent resistant membranes composition

 

CTRL

AA

DHA

EPA

C16:0

33.091 ± 2.128

31.588 ± 1.305

32.446 ± 2.793

35.242 ± 1.836

C16:1

9.598 ± 0.716

9.155 ± 0.742

7.628 ± 2.111

9.443 ± 1.181

C18:0

14.605 ± 0.786

14.957 ± 0.709

16.538 ± 1.964

17.281 ± 0.933

C18:1

31.885 ± 1.922

30.603 ± 1.864

29.766 ± 2.366

30.369 ± 2.772

C18:2

3.511 ± 0.512

3.059 ± 0.934

3.107 ± 0.770

2.950 ± 0.340

C18:3 ω -3

0.351 ± 0.028

0.630 ± 0.052*

0.460 ± 0.011§§

0.480 ± 0.057

C18:3 ω -6

0.480 ± 0.160

0.540 ± 0.183

0.455 ± 0.156

0.435 ± 0.226

C20:3

0.876 ± 0.059

0.700 ± 0.055

0.692 ± 0.032

0.654 ± 0.059

C20:4 (AA)

2.978 ± 0.266

7.599 ± 0.421**

3.093 ± 0.403

2.829 ± 0.395

C20:5 (EPA)

0.711 ± 0.053

0.717 ± 0.396

1.113 ± 0.214

3.498 ± 1.205**

C22:5

0.595 ± 0.141

0.507 ± 0.089

1.011 ± 0.619

0.481 ± 0.201

C22:6 (DHA)

1.320 ± 0.113

1.365 ± 0.113

4.500 ± 1.286**

1.258 ± 0.104

SFA a

47.696 ± 2.853

46.545 ± 1.903

48.984 ± 4.545

48.203 ± 5.614

MUFA b

41.483 ± 2.452

39.759 ± 2.546

37.394 ± 3.993

39.812 ± 3.942

ω -6

7.364 ± 0.609

10.403 ± 0.498*

6.891 ± 0.643

6.433 ± 0.401

ω -3

2.977 ± 0.266

3.218 ± 0.270

7.490 ± 1.974*

5.878 ± 1.461*

ω -6/ ω -3

2.680 ± 0.160

3.141 ± 0.309

1.055 ± 0.287*

1.312 ± 0.378

Fold increase c

 

2.758

3.024

4.821

  1. HT29-dx cells were left untreated (CTRL) or treated with AA, DHA, EPA (50 μM for 48 h).
  2. aSFA: saturated fatty acids; bMUFA: mono-unsaturated fatty acids.
  3. cFold increase: AA, DHA or EPA in treated cells versus AA, DHA or EPA in untreated cells, respectively.
  4. Data are presented as percentage of total fatty acids, mean ± SE (n = 4). Significance versus CTRL: *p < 0.05; **p < 0.01; versus the corresponding treatment in HT29 cells: §§ p < 0.01.