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Table 6 Median and mean fluorescence intensity (MFI) of surface calreticulin (CRT) in HT29 and HT29-dx cells

From: Omega 3 fatty acids chemosensitize multidrug resistant colon cancer cells by down-regulating cholesterol synthesis and altering detergent resistant membranes composition

 

CRT

CRT

Sample

Median

MFI

HT29 CTRL

4.96 ± 0.17

4.29 ± 0.32

HT29 DOX

57.59 ± 4.87*

53.28 ± 6.25*

HT29 AA

8.50 ± 1.69

7.37 ± 0.96

HT29 DHA

9.51 ± 2.14

7.57 ± 0.84

HT29 EPA

10.84 ± 2.39

8.74 ± 1.28

HT29 AA + DOX

65.44 ± 4.91*

67.17 ± 6.32*

HT29 DHA + DOX

70.40 ± 4.85*

58.82 ± 4.82*

HT29 EPA + DOX

68.16 ± 5.13*

59.35 ± 3.31*

HT29-dx CTRL

8.99 ± 1.89

8.51 ± 0.27

HT29-dx DOX

10.08 ± 2.78

10.09 ± 0.31

HT29-dx AA

11.41 ± 2.49

9.06 ± 0.97

HT29-dx DHA

10.85 ± 2.11

8.66 ± 0.41

HT29-dx EPA

6.77 ± 0.82

6.55 ± 0.53

HT29-dx AA + DOX

17.68 ± 5.15

14.72 ± 4.66

HT29-dx DHA + DOX

56.74 ± 4.60*°

46.56 ± 2.64*°

HT29-dx EPA + DOX

56.25 ± 5.21*°

44.11 ± 3.61*°

  1. HT29 and HT29-dx cells were left untreated (CTRL) or treated with AA, DHA, EPA (50 μM for 48 h).
  2. Data were calculated with the Cell Quest software and are presented as mean ± SD (n = 3). Versus CTRL HT29: *p < 0.001; HT29-dx DHA + DOX/EPA + DOX versus HT29-dx DOX: ° p < 0.002.
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Molecular Cancer

ISSN: 1476-4598