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Figure 4 | Molecular Cancer

Figure 4

From: Reduced annexin A6 expression promotes the degradation of activated epidermal growth factor receptor and sensitizes invasive breast cancer cells to EGFR-targeted tyrosine kinase inhibitors

Figure 4

Effects of AnxA6-depletion on the dynamics of total cellular EGFR. A) AnxA6-depleted (BT-A6sh5) and control (BT-EV) BT-549 cells were treated with EGF for 0–90 min and whole cell lysates were analyzed by Western blotting to determine the residual activated and total EGFR. (B-E) Densitometric analysis of residual activated EGFR (B), total EGFR (C) phospho-ERK1/2 (D) and phospho-Akt (E) in BT-EV (solid lines with dark circles) and BT-A6sh5 (broken lines with open circles). Points represent whole cellular EGFR/activated EGFR remaining at the indicated times or activated ERk1/2 and Akt in the control cells (closed circles) and AnxA6-depleted cells (open circles) from a representative experiment.

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Molecular Cancer

ISSN: 1476-4598