Podoplanin expression in cancer-associated fibroblasts enhances tumor progression of invasive ductal carcinoma of the pancreas

Table 1 Relationships between PDPN expression and clinicopathologic factors

Characteristics		PDPN negative, n = 31 (29.5%)	PDPN positive, n = 74 (70.5%)	p Value
Lymphatic invasion	No	11(35.5)	13(17.6)	0.0461^*
Lymphatic invasion	Yes	20(64.5)	61(82.4)	0.0461^*
Vascular invasion	No	17(54.8)	21(28.4)	0.0101^*
Vascular invasion	Yes	14(45.2)	53(71.6)	0.0101^*
Tumor size	<3 cm	23(74.2)	32(43.2)	0.0038^*
Tumor size	≥3 cm	8(25.8)	42(56.8)	0.0038^*
Histologic Grade	G1/G2	20(64.5)	31(41.9)	0.0344^*
Histologic Grade	G3	11(35.5)	43(58.1)	0.0344^*
UICC	pT1/pT2	8(25.8)	7(9.5)	0.0290^*
T category	pT3/pT4	23(74.2)	67(90.5)	0.0290^*
UICC	pN0	14(45.2)	20(27.0)	0.0701
N category	pN1	17(54.8)	54(73.0)	0.0701
UICC stage	I	7(22.6)	5(6.8)	0.0642
	II	23(74.2)	65(87.8)
	III/IV	1(3.2)	4(5.4)

Significant differences between samples are indicated as *P < 0.05. UICC, Union for International Cancer Control.

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