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Figure 1 | Molecular Cancer

Figure 1

From: Effects of HDM2 antagonism on sunitinib resistance, p53 activation, SDF-1 induction, and tumor infiltration by CD11b+/Gr-1+ myeloid derived suppressor cells

Figure 1

p53 activation in 786-0 and A498 RCC xenografts during sunitinib treatment. Lysates were from control (vehicle only), sunitinib, day 3 (sunitinib responding) and sunitinib, day 21 (suntinib resistant) mice. Lanes represent data from individual tumors for each treatment group. Blots were probed for p53, and the p53 dependent genes noxa, hdm2 and p21, as well as hdmx and vinculin.

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