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Figure 3 | Molecular Cancer

Figure 3

From: Effects of HDM2 antagonism on sunitinib resistance, p53 activation, SDF-1 induction, and tumor infiltration by CD11b+/Gr-1+ myeloid derived suppressor cells

Figure 3

Effects of treatment on (A and B) apoptosis (tunel) and (C and D) proliferation in RCC xenografts. In both 786-0 (A) and A498 (B) models, sunitinib induced apoptosis as shown by an increase in tunel positive cells. The addition of MI-319 increased apoptosis in 786-0 but not A498 xenografts. Data is presented as a bar graph showing the mean percent tunel positive cells from six tumors in each treatment group. Sunitinib treatment increased Ki-67 nuclear staining in 786-0 (C) but not A498 (D) xenografts. The Ki-67 staining in 786-0 xenografts from suntinib treatment was suppressed in the presence of MI-319. Data is presented as a bar graph showing the mean percent Ki-67 positive cells from six tumors in each treatment group.

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