The MicroRNA-148/152 Family: Multi-faceted Players

Chen, Yue; Song, Yong-Xi; Wang, Zhen-Ning

doi:10.1186/1476-4598-12-43

Molecular Cancer

Table 1 Targets of miR-148/152 family in various tissues/cells

From: The MicroRNA-148/152 Family: Multi-faceted Players

miR-148/152 family	Expression	Biological function	Targets	Tissues/cells	References
miR-148a			PXR	Human liver	[54]
miR-148a	Upregulation	DNA hypomethylation	DNMT1	CD4+ T cells of Systemic lupus erythematosus	[55]
miR-148a		Tumor growth	CAND1	Human prostate cancer	[50]
miR-148a		Apoptosis	Bcl-2	Colorectal cancer	[56]
miR-148a	Downregualtion	Cell proliferation	p27	Gastric cancer	[57]
miR-148a			HLA-C	HIV-1 infected individuals	[58]
miR-148a			ACVR1	HeLa cell	[59]
miR-148a, miR-152	Downregualtion	Immune rejection	HLA-G	Placenta tissue	[16]
miR-148a	Downregualtion		WNT10B	Cancer-associated fibroblasts	[42]
miR-148a		Cell proliferation,cycle progression,migration	PTEN	Hepatocellular carcinoma	[27]
miR-148a		Cellgrowth, migration,invasion	MSK1	Prostate cancer cells	[41]
miR-148a	Downregualtion	Cell growth	CDC25B	Human pancreatic ductal adenocarcinoma	[37]
miR-148a	Downregulation	Cell invasion and metastasis	ROCK1	Gastric cancer	[5]
miR-148b	Downregulation	Cell proliferation	CCKBR	Gastric cancer	[34]
miR-148b	Downregulation	Cell proliferation	CCK2R	Colorectal cancer	[35]
miR-148a, miR-152	Downregulation		CCKBR?*	Gastrointestinal cancer	[7]
miR-148a, miR-152	Downregualtion	Cell proliferation	DNMT-1	Malignant cholangiocytes	[36]
miR-148b	Upregulation	Glycosylation of IgA1	C1GALT1	IgA nephropathy	[22]
miR-148a, miR-152	Downregualtion	Cell proliferation, colony formation, tumor angiogenesis	IGF-IR, IRS1	Breast cancer	[48]
miR-148a, miR-152	Downregualtion		DNMT1	HBV-related hepatocellular carcinoma	[32]
miR-152			DNMT1?, MLL?	Acute lymphoblastic leukemia	[46]
miR-152		NK cell-mediated cytolysis	HLA-G?	Human trophoblast cell line (JEG-3)	[60]
miR-148/152 family			CaMKIIalpha	TLR-triggered dendritic cells	[15]
miR-152		Cell motility and adhesion	CSF-1	Ovarian cancer cell	[61]
miR-152		Cell growth	DNMT1, Rictor	Endometrial cancer	[62]

*Question mark presents target gene to be further validated.

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ISSN: 1476-4598

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