ERBB3 is a marker of a ganglioneuroblastoma/ganglioneuroma-like expression profile in neuroblastic tumours

Table 2 Histology prediction by 7-GeneSig

		Histology
		NB	GNB	GN	Total:
Predicted	NB	64	0	0	64
	GN	0	1	9	10
	GNB	2	5	1	8
	Total:	66	6	10	82	nd=28
Measure of agreement (Kappa) p= 7.489E-17

Histology prediction was performed on the Versteeg data set (n = 110). Group prediction was based upon the standard deviation (sd) of expression of ALK, BIRC5, CCND1, MYCN, NTRK1, PHOX2B, and ERBB3 according to the rules in Additional file 9. Out of 110 tumours, 82 were successfully assigned and for 28 tumour cases no group belonging could be determined. The groups were assigned as follows: "NB" (r1-r3),"GNB" (r4-GNB), and "GN" (r4-GN). The inter-rate reliability (Kappa) was used to measure the agreement between the assignments of categories (p= 7.489E-17).

ISSN: 1476-4598