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Figure 7 | Molecular Cancer

Figure 7

From: Lyn, a Src family kinase, regulates activation of epidermal growth factor receptors in lung adenocarcinoma cells

Figure 7

Hypothetical working model of ErbB1 homodimers and heterodimers in lipid rafts with RACK1, PKCßII, Lyn and/or Src, Cbp/PAG. EGFR/ErbB1 homodimers are drawn together, independent of ligand, within a single RACK1 complex while ligand-independent heterodimers of ErbB1 and ErbB3 or ErbB1 and c-Met may result from the merging of two or more RACK1complexes. Heterodimers lead to enhanced PI3 kinase activity as illustrated by bolding.

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Molecular Cancer

ISSN: 1476-4598