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Figure 9 | Molecular Cancer

Figure 9

From: Tylophorine, a phenanthraindolizidine alkaloid isolated from Tylophora indica exerts antiangiogenic and antitumor activity by targeting vascular endothelial growth factor receptor 2–mediated angiogenesis

Figure 9

Tylophorine interacted with the ATP-binding sites of VEGFR2 kinase domain. (A) Binding sites of original crystallized bound 42Q and docked tylophorine ligands in volumetric structure in grey colors with VEGFR2 protein (PDB-ID: 3VHE in green ribbon structure) has been created by Chimera program. Both ligands are showing different binding site location. Different types of surface colors of both ligands are showing chemical nature of involved heteroatoms. 42Q ligand has Oxygen (in red colour), Nitrogen (in blue colour), carbon (in grey colour) and Fluorine (in green colour) while Tylophorine contains only Oxygen and carbon heteroatoms. (B) 2-dimensional interaction map of tylophorine and involved amino acids of 3VHE proteins were calculated by LigPlot Software. Key describes the types of involved interaction and bonds.

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Molecular Cancer

ISSN: 1476-4598