Figure 4

Comparative analysis of the expression of validated miRNAs during progression to ADT and CDX resistance. A) Volcano plots depicting significant miRNAs identified by two sample t-test in all treatment conditions compared to untreated -104S cells (1st panel from left), in all CDX treated cells compared to untreated S cells (2nd panel from left), in 3wks CDX treated cells compared to 1wk CDX treated S cells (3rd panel from left) and in all CSFBS treated cells compared to untreated S cells (4th panel from the left). B) Venn diagram using significant miRNAs identified in two sample t-tests (volcano plots) showing common and unique miRNAs between all -104S CSFBS and -104S CDX treated cells. C: List of common up-regulated miRNAs as noted in Venn diagram in all treatment conditions, between 1wk CDX and 3wks CDX and between 3wks CDX and 3wks CSFBS cells. D. List of down regulated miRNAs in all treatment conditions, between 1wk CDX and 3wks CDX and between 3wks CDX and 3wks CSFBS cells.