Figure 5
Cluster analysis of fold change in expression of validated miRNAs in different treatment conditions. A) Hierarchical clustering of log2 transformed FC expression of miRNA in four treatment groups, 1wk CSFBS, 1wk CDX, 3wks CSFBS and 3wks CDX (Table 1). Red arrows and green arrows showing the expression patterns of 21 up regulated and 22 down regulated miRNAs (Tables 2 and 3), respectively. B, C) K-median cluster analysis of the validated miRNAs in different treatment conditions B) Up-regulated miRNAs are divided into 5 clusters, which show unique trends of expressions. All miRNAs in each cluster show similar trends in expression in all treatment conditions and time points. C) Down regulated miRNAS are divided into 7 clusters each showing unique trend of expression pattern of miRNAs. All miRNAs in each cluster is showing similar patterns of expression. Data shows median ± SD of expression of miRNAs in each cluster.