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Table 1 Characteristics of analysed patients-tissue

From: Reduced migration of MLH1 deficient colon cancer cells depends on SPTAN1

Patients

Gender

Age at diagnosis (years)

CRC

MLH1

SPTAN1

Sporadic MLH1+

Sporadic MLH1-(BRAF V600E)

Lynch syndrome MLH1 mutation

Paraffin embedded tissue

       

1.

m

63

x

-

-

+++

+++

2.

m

71

x

-

-

+++

+++

3.

m

46

x

-

-

++

++

4.

m

68

-

x

-

-

+

5.

m

50

-

x

-

-

+

6.

f

67

-

x

-

-

+

7.

m

49

-

x

-

-

+

8.

m

49

-

-

c.275_278delCCAG

-

+

(p.Ala92ValfsX15)

9.

m

57

-

-

c.1731G>A

-

+

(p.Ser577Ser)

10.

m

49

-

-

c.676C>T

-

+

(p.Arg226X)

11.

f

44

-

-

c.583A>T

-

+

(p.Lys195X)

Fresh tissue

12. (N)

m

80

-

-

-

++

+++

12. (T)

-

x

-

-

+

  1. -: deficiency; ++: moderate expression; +++: strong expression; +: weak expression; N: tumour surrounding tissue; T: tumour tissue.
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Molecular Cancer

ISSN: 1476-4598