Classification of patients with PDAC vs patients with chronic pancreatitis. (A) Feature finding results showing the percentage occurrence of cytokines in models following resampling of training data for PDAC vs. chronic pancreatitis. (B) Training set ROC Curves for PDAC vs. chronic pancreatitis for a panel of IL-8, CA19-9, IL-6, IP-10 versus CA19-9 alone. (C) Test set ROC curves for PDAC vs. chronic pancreatitis for the panel of IL-8, CA19-9, IL-6 and IP-10 and CA19-9 alone. (D) The resampling performance of the panel of IL-8, CA19-9, IL-6, IP-10 versus CA19-9 for the classification of PDAC vs. chronic pancreatitis. The accuracies, sensitivities and specificities of the panel compared to CA19-9 alone over 100 patient-balanced resamples is shown. The quantiles of the performance indicators are summarised as boxplots with individual points superimposed and the significance of Friedman test comparisons is indicated (***p < < 0.001).