Figure 4

Classification of patients with PDAC in the presence of jaundice vs. patients with benign disease in the presence of jaundice. (A) Feature finding results showing the percentage occurrence of cytokines in models following resampling of training dataset for PDAC patients with high bilirubin vs. patients with benign disease and high bilirubin. (B) Training set ROC Curves for PDAC patients with high bilirubin vs. patients with benign disease and high bilirubin for a panel of IP-10, IL-8, IL-1b, PDGF and CA19-9 versus CA19-9 alone. (C) Test set ROC curves for PDAC patients with high bilirubin vs. patients with benign disease and high bilirubin for the panel of IP-10, IL-8, IL-1b, PDGF, CA19-9 compared to CA19-9 alone. (D) The resampling performance of the panel and CA19-9 for the classification of high bilirubin PDAC vs. high bilirubin benign disease. The accuracies, sensitivities and specificities of the panel IP-10, IL-8, IL-1b, PDGF, CA19-9 compared to CA19-9 alone over 100 patient balanced resamples is shown. The quantiles of the performance indicators are summarised as boxplots with individual points superimposed and the significance of Friedman test comparisons is indicated (***p < < 0.001).