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Figure 5 | Molecular Cancer

Figure 5

From: Loss of miR-638 in vitro promotes cell invasion and a mesenchymal-like transition by influencing SOX2 expression in colorectal carcinoma cells

Figure 5

SOX2 IHC staining intensity is high in CRC tissues. (A) The staining intensity of SOX2 in the CRC tissue samples was upregulated in 81% of all 90 CRC samples. In addition, the downregulation rate was 6%. The staining intensity was confirmed by a pathologist. (B) The staining intensity score was increased in the CRC tissue samples compared with the adjacent, non-cancerous tissue samples (χ2 = 47.15, p < 0.0001). C) The staining intensity score was correlated with the TNM stage of the CRC tissue samples (χ2 = 32.53, p < 0.0001). (D) The SOX2 staining intensity was increased, as assessed using Image-Pro 6.0 software, and the staining intensity was upregulated by 40.45% in the HCC tissues compared with the adjacent non-cancerous tissue samples. E) and F) A representative image illustrating the upregulation of the SOX2 staining intensity is shown. IHC was performed on 90 pairs of HCC tissue arrays.

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Molecular Cancer

ISSN: 1476-4598